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SOCK FIP...



sockfip

FELINE INFECTIOUS PERITONITIS


F. I. P.


The worst three letters a cat-lover could ever hear.


FRIENDS OF THE FORMERLY FRIENDLESS is proud and excited to be a founding member of the new S.O.C.K. FIP research project. S.O.C. K. is the acronym for Save Our Cats and Kittens. SOCKFIP is a group of cat-lovers, breeders, rescuers, shelters and vets working together to generate essential funding for FIP research at the UC Davis Center for Companion Animal Health. Virtually 100% fatal, FIP strikes 1 in 100 of all cats. We know that most cats acquire the FIP virus early in life, though actual disease signs may not occur until weeks, months or even years later.


Right now, there's no prevention and no cure for FIP. It's time to change all that - and it can be done! Through the very exciting and promising work at UC Davis, we hope to learn how to prevent FIP or find suitable treatments, and spare future generations of cats and cat-lovers this nightmare. Because very little government funding is available for companion animal studies, we are relying on the vast community of cat-lovers to help.


Update on UC Davis FIP Anti-Viral Drug Studies from Dr. Niels Pedersen SUCCESS!!...BUT

Field Trials Completed for now


This last year has been a milestone in our fight against FIP. We extended our landmark studies of 2018 when we published on a collaborative study with colleagues at Kansas State University on a drug called GC376. This was the first drug to successfully cure cats of FIP. In this last year, we reported on a second antiviral drug and its safety and efficacy for the treatment of cats with naturally occurring FIP. This study, which was reported in the April issue of the Journal of Feline Medicine and Surgery, involved a small molecule viral RNA inhibitor called GS-441524. GS-441524 was developed by Gilead Sciences, Inc as part of their research into human RNA virus disease such as Ebola. We initiated this collaboration several years ago with great optimism. Over two years of laboratory work led us to the point of conducting a field trial with owned cats suffering from FIP. This initial field trial did not accept cats with definite neurological involvement based on the difficulty in treating such cats with GC376. GS-441524 proved to be even more potent against FIP and provided hints that even neurological FIP was treatable. Subsequent, and yet to be published, trials with GS-441524 on 4 cats with severe neurological and/or ocular disease have shown GS to be also effective in these most difficult cases if the drug is given at a high enough dosage.

 

We were hopeful that our collaboration with Gilead Sciences would ultimately lead to an FDA approved, commercially available antiviral drug treatment for the many thousands of cats from around the world that are dying from FIP each year. We felt that our results from laboratory and field supported this outcome. Unfortunately, Gilead’s directors concluded at the last minute that something about GS-441524’s use in cats would endanger their ability to get FDA approval for a closely related drug called Remdesivir for humans. Although we strongly pleaded our case for the use of GS-441524 in veterinary medicine, their decision has remained firm.

 

Is the fight against FIP over? The answer is adamantly no! There are undoubtedly even safer and more effective antiviral drugs that can be developed and legally marketed. Oral forms of drugs like GS are required and are even being sold and used in the field at this time. We have already seen how antiviral drug treatment has evolved over the last 40 years in the control of HIV/AIDS and hepatitis C in humans. Nonetheless, it is true that “an ounce of prevention is worth a pound of cure.” We must research better ways to keep and care for unwanted kittens, so they are never exposed to FIP in the first place. An effective vaccine for FIP would be extremely useful in lowering the disease incidence. However, an effective vaccine can only be developed if we first understand how the FIP virus evades the immune system by infecting only macrophages, and how a misdirected immune response by infected macrophages to the virus causes the disease in its various forms. Kitten and cat foster/rescue, formal shelters, and catteries are the three major sources of FIP affected cats. What are the practices in these environments that increase the incidence of FIP? In the case of catteries, what is the importance of genetic factors in FIP susceptibility?

 

for further information  https://sockfip.org/

-NC Pedersen

SUPPORT FIP RESEARCH AND SOCK IT TO FIP!


CHECK

Payable to: SOCK FIP
Mail to: SOCK FIP
P.O. Box 602
Davis, CA 95617

CREDIT CARD

If you would like to make a gift using your credit card,
please call UC Davis at (530) 752-7024.


For more info, please visit the SOCKFIP.org website.

 

WAYS YOU CAN HELP FIGHT F.I.P.

  • Refer friends and family to SOCKFIP.ORG
  • Tell your Veterinarian about SOCKFIP.ORG
  • Distribute SOCKFIP brochures
  • Become a fan of SOCKFIP page on Facebook
  • Contribute to SOCKFIP
  • Ask your club to support F.I.P. Research through donations
  • Ask your employer to match funds to F.I.P. Research donations
  • Hold a fundraiser for F.I.P. Research


S.O.C.K.F.I.P
PRESENTATION...



On The Road

DECEMBER 19,2019, FFF attended a Holiday SOCKFIP meeting at UCDavis Animal Companion Health Center to learn about the ongoing work to conquer FIP.

 

FFF representative, Sally Morgan- Welch, attended the meeting along with our HERO kitty, MEREDITH and FFF new therapy cat trainer, Mr. WHISKERS.

 

Dr. Brian Murphy and graduate student, Sarah Elisabeth Cook, updated SOCKFIP on the current studies being planned and past successes with antiviral drugs.

 

The meeting was particularly poignant as MEREDITH, our HERO kitty was reunited with Dr. Murphy as one of the kitties CURED of wet FIP in their landmark studies on antiviral research.

 

Unfortunately, Dr.Niels Pedersen, the " father of FIP research", was unable to attend due to family emergency. But MEREDITH is due to reunite with Dr.Pedersen soon. It was he who approved the adoption of MEREDITH to FFF founder after her cure from FIP.

 

There is a myriad of antiviral drugs now scheduled for testing and then final FDA approval. Each drug will undergo rigorous testing on private owned cats diagnosed with FIP in the future.

 

 

MEREDITH has become the FACE OF FIP SUCCESS!

 

Sock President - Carol Marshall, and Sock Member Sally Morgan Welch presented Dr. Murphy and his staff with a donation check of $27,000 Along with a personal check from president Carol.

 

Your donations are more important than ever to HELP CONQUER FIP !

 

We are ON THE BRINK OF SUCCESS!



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